The BRAVA Breast Enhancement and Shaping System









		What to Expect
		New Brava Medical and Scientific Studies
		Professional Publications
		Medical Advisory Board
		Clinical Trial Results: Safety
		Clinical Trial Results: Growth

Plastic And Reconstructive Surgery

1. Khouri, RK, Schlenz, I, Murphy, BJ, Baker, TJ. Nonsurgical breast enlargement using an external soft tissue expansion system. Plast Reconstr Surg. 2000;105(7):2500-2514.

Summary: This medical journal article outlines the results from the initial clinical study that were reviewed by the FDA.

You can view the abstract of the above article, Nonsurgical breast enlargement using an external soft tissue expansion system, on-line by visiting The United States National Library of Medicine's web site at www.nlm.nih.gov. Select "HEALTH INFORMATION", then select "MEDLINE/PubMed". You will see a search field with "Pub/Med" entered, you will need to enter the author's name after "for". Type in KHOURI and click on "GO". Scroll down the listings on page one and select page 3. The abstract is referenced by the title as shown above. Double click on the authors of the article and the abstract can be viewed on-screen.

2. DeFillippo RE, Atala A., Stretch and Growth: The molecular and physiological influences of tissue expansion. Plast Reconstr Surg. 2002 Jun; 109(7):2450-62.

Summary: Dr. DeFillippo and Dr. Atala from Harvard University explain how stretch influences lasting tissue growth.

3. Greco RJ, Nonsurgical breast enhancement -- fact or fiction? Plast Reconstr Surg. 2002 Jul; 110(1):337-9.

Summary: Dr. Richard Greco, a plastic and reconstructive surgeon in Savannah, Georgia, conducted an independent study on The Brava System and this article summarizes his findings.

4. Smith, CJ. Initial experience with the Brava Non-Surgical System of Breast Enhancement [letter].

To obtain a reprint of any of the above articles* in their entirety, Plast Reconstr Surg. 2002 Nov; 110 (6):1594-1595

Khouri, RK, Baker, TJ. Reviewers. Plast Reconstr Surg. 2002 Nov; 110 (6):1594-1595. Review of Smith, CJ. Initial experience with the Brava Non-Surgical System of Breast Enhancement.

Summary: Dr. Curran J. Smith, a plastic and reconstructive surgeon in Seattle, Washington, conducted an independent review of the Brava System after the initial 6 months of use in his practice. Dr. Smith discusses his success on a patient with slight asymmetry of the right breast.

Following Dr. Smith's letter is a reply from Dr. Roger Khouri and Dr. Thomas J. Baker that addresses Dr. Smith's issues of proper patient selection. Drs. Khouri and Baker help to profile the ideal Brava candidate.

5. Schlenz, I., Kaider, A., The Brava External Tissue Expander: Is Breast Enlargement without Surgery a Reality? Plast Reconstr Surg. 2007 Nov; 120 (6): 1680-1689.

Summary: Dr. Schlenz and Ms. Kaider revisit the original Khouri, et al, study published in 2000 (see 1. above).

Controlled trials have shown that an external breast tissue expander (Brava; Brava LLC Miami, Fla.) can effectively enlarge the breast without surgery. However, satisfaction with the results has varied among doctors and patients. The first author critically evaluated her clinical experience with Brava and attempted to identify factors associated with a successful outcome.

Using a larger sample and a longer monitoring period, the study confirms and exceeds the results realized in the previous study.

You can view the abstract by using this link.

Please send a written request (be sure to specify which article) to:

Brava, LLC
Marketing/Reprint Request
14221 SW 142 Street
Miami, FL 33186

Please include a self-addressed 9 x 12 envelope and allow 2 to 4 weeks for processing. Please one copy per written request. Additional copies may be obtained by contacting Lippincott Williams and Wilkins (LWW) at http://www.lww.com.

Cosmetic Surgery Times

1. Donley-Hayes, Karen (October 1, 2008). "A look at global trends in breast augmentation". Cosmetic Surgery Times, pp. 22, 24-26.

Summary: This article examines breast augmentation innovations in various stages of development http://cosmeticsurgerytimes.modernmedicine.com/cosmeticsurgerytimes/article/articleDetail.jsp?id=553790

These innovations include alternate types of implants, injectable products, stem cell alternatives and the use of a vacuum assisted device (Brava) combined with fat injection techniques.

In it, Dr. Eisenmann-Klein explains a new technique, pioneered by BRAVA developer Dr. Roger Khouri, which "combine the device with fat injections into the subcutaneous tissue of the breast". Dr. Eisenmann-Klein remarks that after using this technique the results are �impressive�. In this procedure small amounts of fat (only 3 cc or less) are injected into multiple channels in the subcutaneous tissue after gaining the fat by liposuction in the same session. Altogether, up to 300 cc of fat per breast can be injected in one session. The patient wears the BRAVA device for 12 hours per day, beginning 10 days prior to surgery and again from her first postoperative day for 10 days, 12 hours per day." The device increases the volume of the subcutaneous tissue and enables an 80 percent take of the fat grafts on average, Dr. Eisenmann-Klein explains. She indicates that a collaborate exchange of ideas between Dr. Khouri and Dr. Rigotti has lead to the development of a �safe and effective technique� that �will be the future" of breast augmentation. NOTE: This procedure is also referred to as Breast Reconstruction and Augmentation with the Brava Enhanced Autologous Fat Micro-Grafting (for more information see http://www.clinicaltrials.gov/ct/show/NCT00466765?order=1).